African Journal of Pharmaceutical Sciences
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| Volume 5, Issue 2, September 2025 | |
| Research PaperOpenAccess | |
A Retrospective Study of the Combination of Chemotherapy with Phytohemagglutinin (PHA) in the Treatment of Advanced Cancers |
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George Zhu1,2,3* |
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1Khalifa University, United Arab Emirates.
*Corresponding Author | |
| Afr.J.Pharm.Sci. 5(2) (2025) 47-56, DOI: https://doi.org/10.51483/AFJPS.5.2.2025.47-56 | |
| Received: 04/06/2025|Accepted: 10/08/2025|Published: 25/09/2025 |
Background: In current study, I had summarized the retrospective study of cancers under remission, with the combination chemotherapy in conjunction with PHA and/or traditional medicine. Methods: 17 available cancers were entered in combination of chemotherapy plus PHA during 1993-97. The mean age at onset was 45.3 years (range 10-72 years). All other benign neoplasias were not statistically included in this group. Results: In 17 cancers, the rate of Complete Remission (CR) was achieved in 6 advanced patients (35.3%). 3 CR patients with advanced cancers was survival over 10 years, the longest cancer 18 years. Two advanced hepatocellular cancers were successfully treated using chemotherapy and cantharidine and/or traditional medicine, with each 30-years survivors now. A lung cancer was given the combination chemotherapy plus targeting oncogenic receptor EGFR gefitinib therapy, which was in stable disease for 8+ months. Conclusion: In this study, I reported a series of the long follow up of those cured patients with cancers. I experienced that PHA was indeed the stimulation of lymphocytic kill cell activity, thereby exhibiting its anti-neoplastic activity. In previous study, Induction of thyroid neoplasm (thumb size) in 1 postoperative patient with breast cancer was conducted by herb seaweed. The putative mechanism of oncogenic transformation was that iodine contained seaweed drug was participated in the biosynthesis of thyroxine. Oversynthesized thyroxine coupled with its aberrant proto-oncogenic receptor THR (oncogenic thyroid hormone receptor), stimulating the prolonged hyperplasias and metaplasias of thyroid follicular cells, tumor development. Moreover, targeting oncogenic receptor therapy in tumours is currently the third setting, and clinically the standard therapy in hospitals worldwide. This will open a new era of cancer target therapy.
Keywords: Cancer, Chemotherapy, Target oncogenic receptor, Immune therapy, Traditional medicine
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